Possible Interaction: Ascorbate and Vitamin C

“ Ascorbate concentration in both plasma and tears increased with vitamin C supplementation, but the total antioxidant capacity of these fluids did not.”

“Plasma reduced and total ascorbic acid AUC values were significantly higher in both plain and slow release ascorbate groups compared with placebo group.”

“Our study has clearly shown that the oral administration of choline ascorbate , which contains approximately 500 mg of ascorbic acid to the volunteers causes an increase in the blood levels of ascorbic acid.”

“These results demonstrate that the vitamin C content of plants can be elevated by increasing expression of the enzyme responsible for recycling ascorbate.”

“On the other hand, elevation of intracellular concentration of ascorbic acid by treatment with ascorbate 2-phosphate or dehydroascorbic acid makes the cells resistant to the oxidative stress-induced apoptosis.”

“In the early culture stage at which a morphological change in the fibroblasts began to occur, intracellular ascorbate concentrations in low density cultures after addition of ascorbic acid were much higher than in high density cultures.”

“… ascorbate … ascorbic acid : Serum iron concentrations increased in 6 patients; urinary iron excretion showed small peaks a few days after ascorbic acid therapy commenced; haemoglobin concentration … total urinary porphyrin excretion nor the composition of the urinary porphyrins was affected in a way which could be related to ascorbate therapy.”

“Plasma ascorbate concentration (P < 0.05 at every time point) and plasma NO (at resting P < 0.001, immediately after exercise P < 0.05) were significantly increased in the Vitamin C arm than in the placebo arm.”

“In the patients receiving vitamin C , there was a significant increase between day 0 and week 8 in the plasma ascorbate level.”

“Plasma concentrations of ascorbate , but not other physiological antioxidants, increased significantly after short-term supplementation, and increased progressively in the long-term study with increasing vitamin C doses of up to 1000 mg/day.”

“We conclude that vitamin C supplementation in humans dose-dependently increases plasma ascorbate concentrations and, thus, the resistance of plasma to lipid peroxidation ex vivo.”