Possible Interaction: Ascorbate and Ursodeoxycholate

“ UDCA , even at 25 mM concentration, was ineffective on the lipoperoxidation mediated by Fe(2+) alone, but at the same concentration counteracted significantly that by Fe(3+) plus ascorbate , further pointing to its preferential antioxidant interaction with iron(III).”

“…,UDCA significantly inhibited phospholipid liposome peroxidation induced by the OHz.rad;-… system FeCl(3)-EDTA, H(2)O(2) and ascorbate (IC(min): 0.75 mM, IC(50): 3 mM), and by peroxyl radicals generated in the aqueous phase by AAPH (IC(min): 8 mM, IC(50): 14 mM).”