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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ascorbate
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“Overall, ascorbate would exacerbate iron toxicity on intestinal resistance against Salmonella infection through pro-oxidant impairment of intestinal epithelial barrier from extracellular side and/or by facilitating intestinal pathogen colonization.”
Ascorbate exacerbates iron toxicity on intestinal barrier function against Salmonella infection.“However, in the presence of transition metals like iron, ascorbate may give rise to an increased generation of oxidants, and ascorbylation may impose additional carbonyl stress to uremic patients.”
“ Ascorbate markedly increased the release of iron in acidified lysates, and this effect was not reduced by chloroquine.”
“In this work, we significantly lowered the level of iron Fe ) impurities by adding ascorbate in the purification, and the resulting 68GaCl3 could be utilized for high-yield radiolabeling of clinically relevant DOTA-based tracers.”
“This capacity of ascorbate and iron to synergise ferritin iron release has pathological significance, as it lowers the concentration at which ascorbate activates ferritin's iron release to within the physiological range (50–250 &mgr;M).”
“Here we showed, using two prostate cancer cell lines (LNCaP and PC-3) and primary astrocytes, that the anticancer/cytotoxic effects of ascorbate are completely abolished by iron at physiological concentrations in cell culture medium and human plasma.”
“Although ascorbate has long been known to stimulate dietary iron (Fe) absorption and non-transferrin Fe uptake, the role of ascorbate in transferrin Fe uptake is unknown.”
“In fact, the Fe complexes of the HMPIH series prevented the oxidation of ascorbate and hydroxylation of benzoate.”
“Background and Objectives: Since gastric acidity and ascorbate play a critical role in the solubilization and reduction of iron for subsequent absorption, the achlorhydria associated with autoimmune and Helicobacter pylori gastritis may explain the poor response of such patients to oral iron treatment.”
“The addition of ascorbate enhanced iron bioavailability and exposed additional differences in Fe availability among the genotypes.”
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