Possible Interaction: Ascorbate and Ferrous

“Treatment of … with Fe(II) ascorbate altered tight junction permeability in a dose and time-dependent way for up to 3 hr of treatment Upon iron removal and …, the effect was reversible up to 10 microM Fe(II), while at higher concentrations a late phase toxic effect was observed.”

“It also decreased Fe(II) concentration with time, while increasing O2 consumption rate, and impairing the reduction of Fe(III) by ascorbate.”

“Prooxidants, tert‐butyl hydroxyperoxide (BHP), ferrous ions combined with ascorbate or NADPH (via cytochrome P450‐dependent proteins), increased the amount of lipid peroxidation products in the membrane, and in consequence inhibited the reaction.”

“which in turn reacts with Tyr-OH to give Tyr-O.. In the presence of ascorbate , added to reduce the monomeric Fe(III) formed, 80% of the Fe(II ) added produced a radical.”

“In other experiments, of several cations tested, only ferrous and ferric potentiated the above‐described effects of ascorbate.”

“The inhibition was recovered when excessive amounts of ferrous iron and ascorbate were added to the reaction mixture.”

“At 10(-4) M, Fe(II ) and Fe(III) strongly enhanced the chromosome-damaging capacity of ascorbate.”

“ Fe(II ) and Fe(III) (10(-4) or 10(-5) M) reduced or abolished the mitosis-inhibiting action of ascorbate.”

“Whilst the amount of Fe(II ) formed in the presence of ascorbate has resulted in Fh transformation in previous studies, no transformation of Fh to more crystalline Fe(III) (oxyhydr)oxides was observed in this study.”

“Between pH = 6 and pH = 8 a solubility enhancing effect of ascorbate is observed which may be of relevance for the iron absorption from ferrous ascorbate.”

“Incorporation of their Fe(II) complexes in the presence of ascorbate gave a reduction of the phage titer of MS2 phages by several logarithmic decades.”