supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Further studies proved that AA can promote the accumulation of Dox in MCF-7/Adr cells when combined with doxorubicin.”
“The above results suggest that AA could promote the cellular accumulation of doxorubicin by inducing ROS-dependent ATP depletion.”
“We found that combined administration of AA can improve the sensitivity of both MCF-7 and doxorubicin (Dox)-resistant MCF-7/Adr cells to Dox in vitro and in vivo by a reactive oxygen species (ROS)-dependent mechanism.”
Ascorbate promotes the cellular accumulation of doxorubicin and reverses the multidrug resistance in breast cancer cells by inducing ROS-dependent ATP depletion“The effect of ascorbate on doxorubicin efficacy was concentration dependent; low doses were protective while high doses increased cell killing.”
“ Ascorbate had no effect on the antitumor activity of Adriamycin in mice inoculated with leukemia L1210, but it significantly prolonged the life of mice and guinea pigs treated with Adriamycin.”
Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs.“ Adriamycin decreased the rate of ascorbate permeation into the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposomes and DPPC liposomes containing small amounts of phosphatidylglycerol or phosphatidylserine.”
Adriamycin-liposome interactions. A magnetic resonance study of the differential effects of cardiolipin on drug-induced fusion and permeability.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback