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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Artesunate
supplement:
Iron, Dietary
Research Papers that Mention the Interaction
“In conclusion, our results indicate that ferrous iron improves the activity of artesunate in some but not all tumor cell lines.”
“The susceptibility of tumor cells to artesunate can be enhanced by ferrous iron.”
Role of Transferrin Receptor and the ABC Transporters ABCB6 and ABCB7 for Resistance and Differentiation of Tumor Cells towards Artesunate“Our findings suggest that artesunate acts through iron to affect the mitochondria and induce low ROS and non-caspase–mediated apoptosis.”
“It has been demonstrated that Fe could activate the artesunate , leading to the formation of highly reactive carboncentered radicals from AIDs, thus can trigger the alkylation of proteins and generate reactive oxygen species (ROS) to cause cancer cells death.”
A new paradigm for artesunate anticancer function: considerably enhancing the cytotoxicity via conjugating artesunate with aptamer
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