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Last Updated: 3 years ago

Possible Interaction: Artemisinin and Iron, Dietary


Iron, Dietary

Research Papers that Mention the Interaction

Changes in groups receiving both artemisinin and iron gradually became more severe with dose increase.
Turkish journal of medical sciences  •  2017  |  View Paper
Artemisinin generates carbon-based free radicals when it reacts with iron , and induces molecular damage and apoptosis.
Anticancer research  •  2015  |  View Paper
Artemisinin generates cytotoxic free radicals when it reacts with iron.
Anticancer research  •  2014  |  View Paper
Artemisinin reacts with iron to form free radicals that kill cells.
Life sciences  •  2005  |  View Paper
Artemisinin is a chemical compound that reacts with iron to form free radicals which can kill cells.
Expert opinion on therapeutic targets  •  2005  |  View Paper
However, artemisinin enhanced the inhibitory effect of iron (50 microM)-ascorbate (500 microM) on ATPase activity (46.3 +/- 3.9 vs 63 +/- 2.1% for basal; 57.2 +/- 2.5 vs 74.8 +/- 2.1% for CaM-activated).
Biochemical pharmacology  •  1994  |  View Paper
Iron present in hemolyzed plasma could cause the degradation of artemisinin by reductively cleaving the peroxide bridge of artemisinin during sample preparation, which is a significant technical challenge for artemisinin determination.
Biomedical chromatography : BMC  •  2019  |  View Paper
Iron probably catalyzes the generation of free radicals from artemisinin since alpha-tocopherol antagonizes the thiol-oxidizing activity of artemisinin and since a spin-trapped free radical signal can be seen by electron paramagnetic resonance only when artemisinin is incubated in the presence of iron.
Thus, iron plays a role in the mechanisms of action and toxicity of artemisinin.
Antimicrobial Agents and Chemotherapy  •  1993  |  View Paper
The presence of a higher proportion of iron in SIM as compared to M199 significantly enhanced the cytotoxicity of artemisinin in Leishmania promastigotes, and was attributed to a higher degree of iron-mediated cleavage of its EP bridge that led to a higher generation of free radicals.
Free radical research  •  2021  |  View Paper
The activation of artemisinin requires the cleavage of the endoperoxide bridge in the presence of iron sources.
Microbial cell  •  2016  |  View Paper
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