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“A second order degradation reaction (k = 18 M(-1) h(-1)) was observed from the reaction of artemisinin with ferrous sulphate in aqueous acetonitrile to produce a number of stable isomeric rearrangement products.”
Journal of pharmaceutical sciences • 2005 | View Paper
“4] The reductive activation of the peroxide function of artemisinin by iron(II) heme produces a high yield of heme derivatives alkylated at the meso positions by a C-centered radical derived from artemisinin.”