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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Arsenic Trioxide
supplement:
Vitamin C
Research Papers that Mention the Interaction
“In this study, we evaluated the effect of ATO plus AA in patients with non-APL AML.”
“The combination of ATO and AA has limited clinical meaningful antileukemia activity in patients with non-APL AML.”
Adding ascorbic acid to arsenic trioxide produces limited benefit in patients with acute myeloid leukemia excluding acute promyelocytic leukemia“Reducing glutathione by ascorbic acid may enhance the efficacy of arsenic trioxide.”
“We have reported that ascorbic acid (AA) enhances the activity of arsenic trioxide ( As(2)0(3)) against drug-resistant MM in vitro by depleting intracellular glutathione (GSH).”
“As2O3-induced apoptosis was not enhanced by ascorbic acid in normal cells, suggesting that the combination of ascorbic acid and As2O3 may be selectively toxic to some malignant cells.”
“ Ascorbic acid enhanced the antilymphoma effect of As2O3 in vivo without additional toxicity.”
“These two genes might play critical roles in synergetic effects of AA and As2O3 , although the exact mechanism needs further investigation.”
“However, vitamin C enhanced the growth inhibition, death, MMP (∆ψm) loss and GSH depletion by ATO and even strongly increased mitochondrial O2•- levels in ATO-treated HPF cells.”
“While both ATO and ascorbic acid mediate cytotoxicity in CLL B cells as single agents, the efficacy of ATO is enhanced by ascorbic acid.”
“The combination of arsenic trioxide with subtoxic concentrations of ascorbic acid resulted in a sensitization to apoptotic cell death.”
“On the basis of these direct in vitro findings, our studies provide evidence that AA may extend the therapeutic spectrum of ATO.”
“The results of MTT assay indicated that AA exposure potentiates the cytotoxicity of ATO in HL‐60 cells, as evidenced by a gradual increase in MDA levels with increasing doses of AA.”
“In MM, the combination regimens under study incorporate ascorbic acid , which can enhance the efficacy of arsenic trioxide by reducing intracellular glutathione concentrations.”
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