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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Arsenic Trioxide
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“ ATO and sulforaphane co-treatment augmented apoptotic induction as demonstrated by cleavage of caspase-3, -4 and PARP.”
“Like BTZ, sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide ( ATO), an agent with clinical activity in MM.”
“Our results suggest that sulforaphane deserves further investigation in combination with ATO in the treatment of MM.”
“ Sulforaphane in combination with ATO effectively disrupts protein homeostasis through ROS generation and induction of ER stress to culminate in inhibition of protein secretion and apoptotic induction in MM.”
Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways“Cellular exposure to sulforaphane in combination with ATO resulted in a dramatic increase in levels of reactive oxygen species (ROS) compared to treatment with either agent alone.”
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