Possible Interaction: Arsenic Trioxide and Resveratrol

“Co-administration of resveratrol substantially amplified the anticancer effect of As2O3 in NB4 cells.”

“In addition, isobolographic analysis further demonstrated that As2O3 and resveratrol generated a synergistic action.”

“The combination of As2O3 and resveratrol dramatically suppressed both tumor growth and angiogenesis in nude mice.”

“Our findings suggest that resveratrol has a potential effect to alleviate the adverse effect of As2O3 on cardiotoxicity.”

“Results: In this study, we found that both As2O3 and resveratrol can effectively inhibit cell proliferation and promote cell apoptosis in colon cancer, and the combined effect of the two drugs on colon cancer cells is more preeminent.”

“Then we explored pharmacological rescue strategies on As2O3-induced LQTS, and found that 4 therapeutic agents exert rescue efficacy via 3 different … hERG trafficking via promotion of channel-chaperone formation after As2O3 incubation; ranolazine slows hERG degradation in the presence of As2O3; and resveratrol shows significant … triggered by As2O3.”

“These observations suggested that pharmacological chaperone like fexofenadine and resveratrol might have the potential to protect against the cardiotoxicity of As2O3.”

“CONCLUSION RE co uld significantly intensified the effects of As2 O3 in inhibiting the proliferation, depleting GSH content, ROS accumulation, mitochondrial membrane potential decline and cytochrome c releasing, thus leading to cells apoptosis via Cas-3 activation in a mitochondria-dependent pathway.”

“OBJECTIVE To explore the synergistically effects and mechanisms of resveratrol RES ) enhanced the oxidative stress and apoptotic cell death induced by As2O3 (arsenic trioxide).”

“The rate of colony formation, GSH content, mitochondrial membrane potential and apoptosis rate in combination group … significantly lower than that of single RES or As2O3 treatment group (P < 0.05), whereas, RES markedly increased the level of ROS, the expression of cytochrome c and caspase 3 induced by As2O3.”

“The effect of resveratrol against DNA damage was associated with a decreased level of reactive oxygen species and lipid peroxidation in cells treated by As2O3 , suggesting that resveratrol protects against As2O3 toxicity via a cellular anti‐oxidative stress pathway.”

“This was further supported by results showing that resveratrol prevented an increase in the activities and levels of caspases, Fas, Fas‐L, and cytochrome c proteins induced by As2O3.”

“We showed that treatment of HBE cells with resveratrol significantly reduced cellular levels of DNA damage, chromosomal breakage, and apoptosis induced by As2O3.”

“Moreover, resveratrol and As2O3 could also corporately enhance the … Fas and FasL. Together, our results suggest that resveratrol … As2O3 synergistically increase the apoptotic cell death in A549 cells through induction of oxidative stress, indicating … promising strategy to increase the clinical efficacy of As2O3 in the treatment of lung tumor.”

“Our data revealed that co-treatment with resveratrol and As2O3 caused more genotoxicity and serious oxidative stress in A549 cells than that of single agent treatment.”

“Our results showed that co-treatment of resveratrol with As2O3 resulted in a synergistic augmentation of cytotoxicity and apoptosis in cells at the tested concentration.”

“Moreover, a dose-dependent iAs accumulation was observed in serum and brain tissues of mice receiving As2O3 alone whereas simultaneous administration of As2O3 with RES facilitated iAs efflux.”

“Our collective findings indicate that ATO and Rsv synergistically enhance the sensitivity of drug-resistant leukemia cells to apoptosis.”

“ Rsv … ATO and reduced the required dose of ATO as well as associated adverse reactions by promoting the proliferation inhibitory and apoptosis-inducing effects of ATO, …/MRP1 and bcrp/BCRP, as well as the apoptotic inhibitory genes bcl-2, NF-κB and P53, and conversely, activation of caspase-3.”