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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Arsenic Trioxide
supplement:
Paricalcitol
Research Papers that Mention the Interaction
“Exposure to As2O3 decreased levels of PML-RARalpha in PR9 cells, and the combination of paricalcitol and As2O3 enhanced their monocytic differentiation in parallel with the As2O3-mediated decrease of PML-RARalpha.”
“Furthermore, As2O3 increased the transcriptional activity of paricalcitol probably by increasing intracellular levels of paricalcitol by decreasing the function of the mitochondrial enzyme 25-hydroxyvitamin D3-24-hydroxylase, which functions to metabolize the active vitamin D in cells.”
“In summary, the combination of paricalcitol and As2O3 potently decreased growth and induced differentiation and apoptosis of AML cells.”
“ Paricalcitol , when combined with As2O3 , showed a markedly enhanced antiproliferative effect against acute myeloid leukemia (AML) cells.”
19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.
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