Possible Interaction: Arsenic Trioxide and Genistein

“Our results demonstrated that genistein not only potentiated the proliferation-inhibiting and apoptosis-inducing effect of ATO on human HCC cell lines in vitro, but also dramatically augmented its suppressive effect on both tumor growth and angiogenesis in nude mice.”

“The aim of the present study was to determine whether genistein , a natural Akt/NF-κB inhibitor, could enhance the anti-HCC efficacy of ATO both in vitro and in vivo.”

“Combining genistein with ATO warrants investigation as a therapeutic strategy to combat HCC.”

“ Genistein exhibits anticancer and pro‐oxidant activities, making it a potential candidate to enhance the efficacy of ATO whose cytotoxicity is oxidation‐sensitive.”

“This study sought to determine whether genistein synergizes with ATO to combat hepatocellular carcinoma (HCC).”

“In this regard, we recently reported that genistein potentiates apoptosis induction by the anti-leukaemic agent arsenic trioxide (ATO) via reactive oxygen species (ROS) generation and p38-MAPK activation.”

“By contrast, N-acetyl-L-cysteine and p38-MAPK inhibitor attenuate the apoptosis-sensitizing (pro-apoptotic) action of genistein when combined with the antileukaemic agent arsenic trioxide.”

“The pro‐oxidant capacity of genistein might be exploited to improve the efficacy of ATO as anti‐leukemic agent, and perhaps the efficacy of other oxidation‐based therapeutic approaches.”

“ Genistein , a kind of PTK inhibitor, could decrease the increase of [Ca(2+)]i treated by 2, 5, 10 micromol/L As2O3 in a dose-dependent manner.”