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“Mechanistically, Aripiprazole caused depletion of ER calcium , leading to activation of inositol-requiring enzyme 1 (IRE1)and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), two major transducers of the UPR.”
The Journal of Pharmacology and Experimental Therapeutics • 2020 | View Paper
“Mechanistically, Aripiprazole caused depletion of ER calcium , leading to activation of inositol-requiring enzyme 1 (IRE1)and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), two major transducers of the UPR.”