Possible Interaction: Arginine and Vitamin C

“However, the greater response of … L-arginine and to Vitamin C co-… L-arginine in these young patients suggests that decreased substrate availability for NO synthase and oxidative stress are key factors … alterations in endothelium-dependent vasodilation of the renal vasculature in this young high risk group of patients.”

“The response of RPF to infusion of L-arginine was more pronounced in high risk patients than in control …/min versus +75.6+/-60.2 ml/min, p=0.012) and further exaggerated during co-infusion of L-arginine … Vitamin C (+299+/-164 ml/min …/min, p=0.003).”

“Co-infusion of vitamin C and l-arginine dilated proximal coronary segments by 8.68 (1.40)% (p < 0.01 v normal saline, p < 0.01 vl-arginine) and distal segments by 13.07 (2.15)% (p < 0.01 v normal saline, p < 0.01 vl-arginine).”

“Thus, vitamin C may have beneficial effects on nitric oxide bioavailability induced by l-arginine.”

“A combination of 5.74 mM of arginine and 0.57 mM of ascorbic acid induced HA22T/VGH cell death through apoptosis and an increase in levels of reactive oxygen species and NO, as well as its stable products NO(2)(-) and NO(3)(-).”

“After administration of L-arginine to restore baseline perfusion, the co-infusion of vitamin C led to a lesser increase of RPF in females than in males (+37 +/- 86 versus +60 +/- 52 ml/min/1.73 m(2), P = 0.05).”

“Gene–environment interaction between disease (diabetes) and genotype (genotype GG vs. genotype GT/TT) was observed for increase of RPF to coinfusion of vitamin C with L-arginine (P=0.020).”

“In patients … of vitamin C … L-arginine than homozygous carriers of the G allele (61.8±75 vs. 22.3±73 ml/min/1.73 m2, P=0.…-arginine was similar between both groups (46.2±80 vs. 70.7±86 ml/min/1.73 m2, P=0.217).”

“Co-infusion of the antioxidant vitamin C on top of L-arginine induced a more pronounced increase in RPF in patients with chronic glomerular disease than in control subjects (21.7+/-17 vs 10.9+/-22%; P=0.036).”

“In contrast, vitamin C induced a more pronounced increase in RPF in diabetic than in non-diabetic patients when co-infused with L-arginine (+71+/-47 and +43+/-33 ml/min/1.73 m(2); P<0.05).”

“Supplementation with both oral L-arginine (the physiologic substrate for nitric oxide) and vitamin C (an aqueous phase antioxidant) may improve endothelial function; however, their benefit in cigarette smokers is not known.”

“ L-Arg plus vitamin C enhanced L-Arg effect on TAS and protected against TNF-α increase.”

“The addition of vitamin C to the BH4 + L-arginine regimen further increased these dependent variables.”