Possible Interaction: Arginine and Vasodilator Agents

“Long-term oral therapy with L-arginine reduced endothelial dysfunction and inhibited the development of atherosclerosis, but the mechanisms by which it exerts its vasodilator effect are not completely understood.”

“Our findings suggest that a vasodilator effect of NO induced by L-arginine loading may, at least in part, be associated with increased renal sodium excretion in patients with chronic renal failure.”

“Systemic infusion of L-arginine induced renal vasodilation and natriuresis in normotensive subjects, an effect which seems to be mediated mainly by intrarenal NO production.”

“ L-arginine … vasodilator response to acetylcholine in control subjects (maximum flow decreased from 16.4±8 to 7.01±3 mL min'1 100 mL1; p<0.… alter the response to acetylcholine in hypertensive patients (maximum flow, 8.2+4 versus 8.01±5 mL. min1 100 mL'1).”

“Release of this vasodilator was enhanced by arginine analogs, including Nω-nitro-l-arginine (a NO synthase inhibitor), suggesting that it is not NO.”

“In conclusion, renal vasodilation is more sensitive to L-arginine during salt restriction.”

“Infusion of L-arginine , the substrate for nitric oxide synthase, causes renal vasodilation.”

“Concomitant infusion of L-arginine prevented the inhibitory effect of L-NNA on renal vasodilation induced by intrarenal infusion of AVP in the presence of the V1-antagonist.”

“In control rats, L-arginine infusion induced a vasodilatory response of AR and ER, and elevation of QA and Kf, which resulted in a 72.6% increase in SNGFR.”

“Production of the vasorelaxant was enhanced by 0.5 mM L-arginine and inhibited reversibly by NG-methylated L-arginine analogs that block macrophage NO2-/NO3- synthesis.”