Possible Interaction: Arginine and Vasoconstrictor Agents

“AIMS It has been suggested that provision of the substrate of nitric oxide (NO) synthesis, L-arginine , might influence the effects of renal vasoconstrictors.”

“In addition, there appears to be a relationship between arginine and vasopressor need after bypass surgery.”

“The authors demonstrate that skin vasoconstriction induced by cigarette smoking in normal volunteers is due to a concomitant enhancement of arginine vasopressin release.”

“Supplementation of L‐Arg reversed the vasoconstrictor effects of AngII and restored pressure‐dependent diuresis to levels not significantly different from control rats.”

“ L-arginine (L-Arg, 10 &mgr;M) similarly inhibited the vasoconstrictor responses in both strains; however, the inhibitory effect of 100 &mgr;M of L-Arg was greater in MCA from SHR.”

“The attenuated vasoconstrictor response to ET-1, but not that to methoxamine, was further attenuated by chronic treatment with L-arginine.”

“These findings suggest that the augmented vasoconstriction of the coronary artery induced by ET-1 in hypertensive hearts was due to a reduction in nitric oxide release in coronary vessels and that L-arginine can partially inhibit the vasoconstrictive response of the coronary artery.”

“9+/-4.8 versus +48.3+/-9.1 mm Hg, P<0.05), and further infusion of the biological ecNOS substrate L-arginine (0.5 g/kg) was ineffective in reversing systemic vasoconstriction (-1% versus 28% vasodilatation, P<0.001).”

“It is concluded that L-arginine-NO pathways act in vivo to oppose peripheral vasoconstrictor influences coupled with central cholinergically mediated activation of the adrenergic system, as produced by physostigmine.”