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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“ l-Arginine could extend our conventional treatment options for valproic acid overdose.”
L-Arginine in the treatment of valproate overdose – five clinical cases“Serum levels of Arg in male ENP and HArg in both sexes of ENP taking valproic acid were significantly lower than those in ENP not taking valproic acid.”
“ l-Arginine , the substrate of iNOS, restores the promotion effect of VPA , being against MDLA.”
Valproic acid up-regulates the whole NO-citrulline cycle for potent iNOS-NO signaling to promote neuronal differentiation of adipose tissue-derived stem cells.“Pharmacokinetic increase in total brain AED concentrations was observed for the combinations of L-Arg (500 mg/kg) with 7NI (150 mg/kg) and PHT (by 32%; p<0.01) or VPA (by 22%; p<0.05).”
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