Possible Interaction: Arginine and Urea

“A significant increase in urea and aspartate transaminase levels in patients receiving active L-arginine treatment was observed.”

“ Urea production and excretion were reduced significantly with arginine supplementation, suggesting an anabolic effect on the whole body nitrogen economy, possibly via the raised plasma insulin levels (P = 0.013) during the prandial phase.”

“Our laboratory previously reported that uremic levels of urea inhibit L-arginine (L-Arg) transport into endothelial cells.”

“In dogs, after intraduodenal administration of arginine in vivo , concentration of urea increased, both in the blood from the portal vein and in peripheral blood.”

“With regard to caries, this would include alkali-generating substances such as urea and arginine, … bacteria, resulting in ammonia production and increase in pH. While there is no evidence that urea added to chewing gums or mouth …, multiple studies have shown that arginine in consumer products … the caries process.”

“In critically ill septic patients, the synthesis of arginine can be exceeded by its catabolism to nitric oxide (NO) and urea , rendering arginine conditionally essential.”

“When expressed on a molar basis, arginine administration resulted in an almost stoichiometric rise in urinary urea excretion.”

“Further decreases in LHF separation were seen upon incubation with urea and arginine.”

“Supplementation with l-arginine increased plasma concentrations of arginine, ornithine, proline, homoarginine, urea , and nitric oxide metabolites without affecting those for lysine, histidine, or methylarginines, while reducing plasma concentrations of ammonia, glutamine, free fatty acids, and triglycerides.”

“However, arginine treatment resulted in lower serum concentrations of leptin, glucose, triglycerides, urea , glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance.”