Possible Interaction: Arginine and Trypsin

“ Trypsin cleaves at substrate arginine and lysine peptides bonds.”

“Although more than one component of serum has been shown to be capable of hydrolyzing these substrates, it has been suggested that trypsin may be elevated in pancreatic disease and could conceivably account for the enhanced hydrolysis of the arginine substrates.”

“ Trypsin PC was found to hydrolyze amide bonds formed by carboxylic groups of lysine and arginine in peptide substrates.”

“Decreased inhibitory activity of the trypsin domain was observed with casein and benzoyl arginine ethyl ester as substrates.”

“Pretreatment of the cells with trypsin , which removed Fc epsilon R , markedly diminished the release of IgE-potentiating factor, suggesting that the factor is derived from Fc epsilon R on the cell surface.”

“In the presence of arginine and N-substitute arginines, the elution of trypsin was accelerated.”

“The homologues with either lysine or arginine in the P1 position are equally good inhibitors of trypsin , plasmin and kallikrein.”

“It was … that trypsin cleaves the C-terminal … lysine (K) and arginine (R) residues with higher rates for R. And the cleavage sites surrounded by neutral residues could be quickly cut, while those with neighboring charged residues (D/E/K/R) or proline residue (P) could be slowly cut.”

“Modification at lysine and arginine residues, in particular, causes resistance to digestion by trypsin , producing large tryptic peptides that are not readily sequenced by mass spectrometry.”

“ Trypsin cleaves the peptide bond between the carboxyl group of arginine or the carboxyl group of lysine and the amino group of the adjacent amino acid.”