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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Tolbutamide
Research Papers that Mention the Interaction
“ tolbutamide without themselves being an appropriate signal for C-peptide release amplify the response to a subsequent arginine infusion under appropriate conditions.”
The effect of glucose, tolbutamide, and arginine on C-peptide release during remission in type I diabetes mellitus“The amino acid substitution Cys-144 ->Arg increased both the rates of tolbutamide and phenytoin hydroxylations, while the Leu-359-->Ile change had a greater effect on phenytoin hydroxylation.”
“Islets cultured in the presence of 10 mmol/L L-arginine had reduced responses to glucose (delta AUC, 11% of control) and tolbutamide (delta AUC, 27% of control), but responded to L-arginine (delta AUC, 75% of control).”
“The markedly exaggerated insulin response was observed after arginine stimulation; tolbutamide infusion produced an abnormal but less exaggerated response than seen with glucose or arginine.”
“ Tolbutamide treatment markedly depressed the IRI response to glucose (P less than 0.005) or arginine (P less than 0.0005) infusion and the IRG response to arginine (P less than 0.01).”
Suppressive effect of long term sulfonylurea treatment on A, B, and D cells of normal rat pancreas.“In addition, tolbutamide treatment increased the glucagon response to arginine in normal, but not in hypox rats.”
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