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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“The interaction between rtPA and L-arginine may be leading to the production of nitric oxide, which can cause direct neurotoxicity, altered cerebral blood flow, and disruption of the neurovascular unit.”
The Contribution of L-Arginine to the Neurotoxicity of Recombinant Tissue Plasminogen Activator following Cerebral Ischemia: A Review of rtPA Neurotoxicity“Pretreating the samples with arginine decreased or abolished immunofluorescence staining for PAI-1 and t-PA , but not for VN.”
“Results After exposing the cultured mouse retinal cells to tPA plus L-arginine or L-arginine alone, cyclic-GMP concentrations were 61.9 ± 5.1 pmole/mL and 63.1 ± 6.1 pmole/mL, respectively.”
Effect of Amiloride to Retinal Toxicity Induced by Tissue Plasminogen Activator“ l-Arginine seems to be the major factor in retinal toxicity of commercial tPA (containing l-arginine).”
“Thrombolysis with use of tPA coupled with L-arg resulted in an increase in EDR (95% +/- 4.9; ACh = 15 micro g/min; n = 5; P =.007).”
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