Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Arginine and Tetrahydrobiopterin

Research Papers that Mention the Interaction

BH4, L-arginine, or BH4 plus L-arginine inhibited eNOS monomerization.
Scientific Reports  •  2019  |  View Paper
In the presence of both l-arginine and tetrahydrobiopterin , eNOS is highly coupled (>90%), and the measured stoichiometry of O2/NADPH is very close to the theoretical value.
Journal of Biological Chemistry  •  2007  |  View Paper
Inhibition and reconstitution of pteridine synthesis in activated murine macrophages by specific drugs demonstrate that tetrahydrobiopterin regulates the amount of nitrogen oxides formed from arginine in intact cells, thus providing a rationale for therapeutic intervention.
Pathobiology : journal of immunopathology, molecular and cellular biology  •  1991  |  View Paper
This cofactor is absolutely required for all aromatic amino acid hydroxylations, and, recently, nitric oxide production from L-arginine has also been found to be dependent on tetrahydrobiopterin.
American journal of human genetics  •  1993  |  View Paper
In the ischemic hindlimb, cosupplementation with BH4 + L-arginine resulted in greater eNOS and phospho-eNOS (P-eNOS) expression, Ca2+-dependent NOS activity and NO concentration in the ischemic calf region (gastrocnemius), as well as greater NO concentration in the region of collateral arteries (gracilis).
Rats receiving cosupplementation of BH4 + L-arginine led to greater recovery of foot perfusion and greater collateral enlargement than did rats receiving either agent separately.
Molecular medicine  •  2012  |  View Paper
Cosupplementation with BH4 + L-arginine resulted in greater eNOS expression, Ca2+-dependent NOS activity and NO concentration in gastrocnemius from the ischemic hindlimb, as well as greater recovery of foot perfusion and more collateral artery enlargement than did rats receiving either agent separately.
Molecular medicine  •  2012  |  View Paper
Thirdly, tetrahydrobiopterin enhances cardiomyocyte NO synthesis by augmenting l-arginine uptake, presumably by modulating CAT-2A expression (Schwartz et al. 2001).
The Journal of physiology  •  2007  |  View Paper
Pretreatment with BH4 (10-5 M) enhanced the vasodilator responses to L-Arg in the Ovx group compared with the untreated Ovx group.
Menopause  •  2006  |  View Paper
L-arginine and tetrahydrobiopterin administration both resulted in a significant preservation of tissue NO concentrations and an improvement in LDF, compared to control animals given saline.
Journal of neurotrauma  •  2004  |  View Paper
It is concluded that (a) BH4 does not regulate the intracellular concentration of …) less binding of BH4 to NOS occurs in BH4 deficiency states; (c) BH4 has a potent effect … of NOS for arginine ; and (d) the availability of arginine for NOS … become severely limiting in BH4 deficiency states.
Journal of Inherited Metabolic Disease  •  2004  |  View Paper
Show More