Possible Interaction: Arginine and Spermine

“Addition of spermine or knockdown of CAT2 inhibited L-Arg uptake, NO production, and iNOS protein levels, whereas knockdown of ODC had the opposite effect.”

“The antiaggregating effect of L‐arginine and polyamines (putrescine, spermidine and spermine ) was studied in platelets of normal and diabetic rats (120 mg/Kg alloxan, i.p.).”

“These results show that L‐arginine and the polyamines putrescine, spermidine and spermine have an antagonist action in platelet aggregation.”

“In contrast, application of the mixed system comprising SPM and STC significantly increased not only the R of the large pathways but also ε/L of the small pathways.”

“We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood.”

“The inhibitory effect of spermine on the phosphorylation of the 11,000-dalton protein was specific, other cations such as ammonium chloride, arginine , putrescine, cyclen and trien were ineffective at equal molar or much higher concentrations.”

“Intraperitoneal injection of arginine to intact animals increases the arginase activity and the brain content of spermidine and spermine by 15, 19 and 25%, respectively.”

“The combination of spermine and arginine was more effective in stimulating albumin synthesis than either agent alone.”

“A parallel induction is observed on spermine and spermidine accumulation, particularly evident when arginine is used.”

“Exogenous chitosan and spermine improved the level of PAs by regulating arginine decarboxylases, S-adenosyl methionine decarboxylase, copper-containing amine oxidase and polyamine oxidase activity, and expression of the genes encoding these enzymes under drought.”

“Exogenously added polyamines had little effect on ornithine decarboxylase, whereas S-adenosylmethionine and arginine decarboxylase activities rapidly diminished with added spermidine or spermine.”