Possible Interaction: Arginine and Somatostatin

“ Arginine stimulates growth hormone (GH) secretion, possibly by inhibiting hypothalamic somatostatin ( SS ) release.”

“We infer from the present data … GHRH and somatostatin, 2) L-arginine … somatostatin release, 3) GHRP-2 could further enhance the stimulatory impact of exercise by opposing central actions of somatostatin … strongly controls the relative but not absolute magnitude of A/G synergy both at rest and after exercise.”

“We tested the possibility that lysine vasopressin (LVP) changes the GH responsiveness to exogenously administered GH‐RH (… its minimal and maximal doses), clonidine (which is thought to stimulate endogenous GH‐RH release) and arginine (which is … to inhibit somatostatin ) in patients with type 1 diabetes mellitus and normal subjects.”

“ L-arginine given intravenously at a dose of 300 mg/kg/h significantly increased plasma glucagon and somatostatin in fasted patients and increased postprandially released glucagon without affecting postprandial plasma somatostatin levels.”

“Pyridostigmine and arginine inhibit hypothalamic somatostatin tone.”

“Because L-dopa is believed to release GH by stimulating endogenous GHRH, whereas arginine may act by suppressing endogenous somatostatin secretion, we propose that blindness may impair GH release by inhibiting GHRH secretion.”

“Studies … with L-arginine, … somatostatin secretion, have demonstrated a vigorous growth hormone response in older person^.^-^ In addition, somatostatin antisera increased growth hormone to a greater extent … rodent^.^ In this issue of JAGS, Mulligan et aL6 demonstrate that somatostatin inhibits growth hormone secretion in both young and older persons.”

“We conclude that the stimulatory effects of Arg are mediated by suppression of endogenous somatostatin secretion.”

“Parenteral administration of synthetic SRIF inhibits the release of growth hormone, basal and stimulated by muscular exercise, arginine , L-DOPA, insulin-induced hypoglycemia, and sleeping.”

“In man, 3 mug per kg per 90 min of linear somatostatin significantly inhibited basal as well as arginine induced insulin and glucagon release.”

“In the perfused rat pancreas, as little as one ng per ml of perfusate of somatostatin significantly inhibited argine induced insulin but not glucagon release, while 10 ng per ml of somatostatin by more than 50 per cent reduced the effect of arginine on insulin and glucagon release.”