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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Simvastatin
Research Papers that Mention the Interaction
“The combination of L-arginine with simvastatin led to a significantly stronger reduction in triglycerides compared to placebo plus simvastatin (-140.5 +/- 149.2 mg/dL vs -56.1 +/- 85.0 mg/dL; P = .048).”
“We conclude from our data that L-arginine enhances the effects of simvastatin on lipid metabolism, but it has no triglyceride-lowering effects when given alone.”
L-Arginine enhances the triglyceride-lowering effect of simvastatin in patients with elevated plasma triglycerides.“Combination of simvastatin with oral L-arginine improves endothelial function in subjects with high ADMA, but has no additional effect in subjects with low ADMA.”
“In subjects with low ADMA, simvastatin improved endothelial function when given alone (9.5 +/- 3.2% vs. 6.1 +/- 3.8%; p < 0.001) or in combination with L-arginine (9.0 +/- 3.1% vs. 6.3 +/- 3.3%; p = 0.001).”
“ Simvastatin co-administrated with arginine or citrulline increased NO production, but at simvastatin 10 μM, 1 mM arginine-induced NO production was significantly (P < 0.01) higher than 1 mM citrulline-induced NO production.”
“ Simvastatin induced an increase in eNOS mRNA expression and protein levels in the presence of arginine or citrulline.”
Arginine or citrulline associated with a statin stimulates nitric oxide production in bovine aortic endothelial cells.“The gastroprotective effect afforded by simvastatin was significantly augmented by coadministration with L-arginine (a nitric oxide precursor) and inhibited by coadministration with L-NAME (a nitric oxide synthase inhibitor).”
“ Simvastatin also inhibited the [Ca2+]i increases by L‐arginine and KCl, agents that act via opening of L‐type Ca2+ channels.”
“Results indicated that treatment with simvastatin significantly enhanced levels of GPx and GST and decreased lipid peroxide levels induced by L-arginine compared to the vehicle.”
“These findings pointed out the protective role of simvastatin against acute pancreatitis induced by high doses of L-arginine.”
Antioxidant activity of simvastatin prevents L-arginine-induced acute toxicity of pancreas.
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