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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Sildenafil
Research Papers that Mention the Interaction
“This association in based on the principle that L-Arginine , the precursor of nitric oxide, improves the effect of Sildenafil , which is effective in the presence of nitric oxide.”
[Erectile disfunction after non nerve-sparing radical pelvic surgery].“This association is based on the principle that L-Arginine , the precursor of nitric oxide, improves the effect of Sildenafil , which is effective in the presence of nitric oxide.”
“The use of sildenafil combined with L-arginine further facilitates erections and it may benefit men with more severe erectile dysfunction.”
“We tested a hypothesis whether a combination of L-arginine and PDE-5 inhibitor sildenafil has an additive effect in reduction of the hypoxic pulmonary hypertension (HPH) in rats.”
L-arginine in combination with sildenafil potentiates the attenuation of hypoxic pulmonary hypertension in rats.“We also investigated whether N(G) nitro-l-arginine methyl ester (l-NAME) and sildenafil , both modulators of the arginine metabolism, restrain tumor growth and restore tumor-specific immunity.”
“High-fat–fed mice treated with sildenafil plus l-arginine or sildenafil alone for 12 weeks had reduced weight and fat mass due to increased energy expenditure.”
“In addition, a subeffective dose of sildenafil induced an additive proconvulsant effect when combined with either L‐arginine or SNP.”
“However, significant decreases in mean pulmonary artery pressure were observed 30, 45, 60, and 75 min after the administration of sildenafil alone or after the combined administration of sildenafil and L-arginine (all P < 0.05).”
“Lower and per se noneffective dose of sildenafil (10 mg/kg) and l-arginine (60 mg/kg), when coadministered, exerted a significant place conditioning.”
“In addition, the combination of less effective doses of sildenafil and l‐arginine has a potential advantage on erectile functions.”
“ Sildenafil (1 × 10−9 and 1 × 10−8 m) potentiated the EFS‐induced relaxation caused by l‐arginine (3 × 10−5 m).”
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