supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Research Papers that Mention the Interaction
“The activity of thrombocytin on this substrate and on platelets was inhibited by diisopropyl fluorophosphate (DFP), soybean trypsin inhibitor, and several arginine chloromethyl ketones.”
Thrombocytin, a serine protease from Bothrops atrox venom. 1. Purification and characterization of the enzyme.“Incubation of the islets with serotonin (4 ×10−3mol/l) was associated with an inhibition of glucagon output both in the basal medium (3.3 mmol/l glucose) and in the presence of arginine (10 mmol/l).”
Inhibition of glucagon release by serotonin in mouse pancreatic islets“RESULTS In vessel rings precontracted with norepinephrine, potassium chloride, ar inine va sopressin, prostaglandin F(2alpha), or ser otonin, H b elicited significant additional contractions.”
“Superfusion with the precursor of NO, L-arginine , for 1 h led to a sustained increase in 5-HT release.”
“We found that 5-HT stimulated the conversion of [3H]L-arginine ([3H]L-Arg ) to [3H]L-Cit, indicating eNOS activation.”
“However NO generators, sodium nitroprusside, 3-morpholinosydnonimine and S-nitroso-N-acetylpenicillamine as well as NO precursor, L-arginine markedly inhibited 5-HT induced HTR in mice.”
“ L-arginine also improved the impaired endothelium-dependent relaxations to ADP, and normalized the vasoconstrictor effects of 5-HT in isolated aortic rings.”
“Chronic inhibition of the L-arginine pathway increased the response of the basilar artery to serotonin , while the opposite was found for endothelin.”
“Nitro-L-arginine methyl ester, nitro-D-arginine methyl ester, L-Arg, D-Arg, L-arginine methyl ester and L-arginine ethyl ester , at the dose of 15 mumol/paw, significantly potentiated both bradykinin- and 5-hydroxytryptamine-induced oedema.”
“ 5-hydroxytryptamine , whose antidiuretic effect was previously established, enhanced R in longitudinal muscular cells, and was able to increase R slightly in epithelial cells.”
“Both of the neuronal molecules, which act via distinct transduction pathways (phosphoinositide turnover for neuroparsin, and Ca(2+)-dependent adenylate cyclase for 5-hydroxytryptamine ), stimulated an increase in R by causing Ca2+ entry through dihydropyridine-sensitive Ca2+ channels.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback