Possible Interaction: Arginine and Serine

“ Arginine resulted significantly increased (Arg: 1.9 times the reference) and cystine (Cys: 0.45), serine (Ser: 0.8) and taurine (Tau: 0.85) remained significantly lower than “normal” as well as the not administered citrulline (Cit: 0.58) and alfa amino butyric acid (Aba: 0.41).”

“ Serine paired with arginine (ion‐paired amino acid, IPA) shows enhanced lipophilicity, skin permeation, and exfoliation efficacy.”

“Thus, we suggest perilipin 1A and HSL are differentially phosphorylated in a similar manner at the initiation of lipolysis and arginine residues near the target serines may influence this process.”

“Mutation of serine to other amino acids with varying side chains: alanine, methionine, leucine, aspartic acid, asparagine, and arginine also resulted in significant activation, indicating a serine-specific inhibitory effect.”

“The functional tests of the TSH receptor gen mutation, detected in family 2, are ongoing, but an exchange of serine by arginine at the same position has been shown to lead to constitutively active cAMP accumulation.”

“By contrast, in CSF, serine , threonine, and tyrosine decreased (-20, -24, and -31%, respectively) after R feeding.”

“Whereas phosphorylation introduces a bulky negative charge group, mutation of serine to arginine introduces a bulky positive charge.”

“After reflow, L-arginine supplementation increased the pool of glutamate and arginine and limited the depletion of serine , asparagine, glycine and taurine.”

“The consumption of arginine and serine was observed in parallel with the production of ornithine, proline, citrulline, glycine, and urea.”

“… serine … arginine residues is critical, as elucidated in [4] using synthetic dodecapeptides of the general sequence: (Gly),-Arg-Arg-(Gly)y-Ala-Ser-Leu-Gly and … required structure of substrates of cyclic AMPdependent protein kinase is met also by the general structure Lys-Arg-X-X-&r-X [3].”