Possible Interaction: Arginine and Proline

“Amino acid metabolism was stimulated in tumor-bearing animals after receiving 4 or 6% arginine , demonstrated by significant increase of arginine, ornithine, citrulline, proline and histidine levels in the blood (p ≤ 0.001) when compared to the control diet group.”

“AI is also expressed in various extrahepatic tissues and may play a role in regulating arginine levels and in providing ornithine for biosynthetic reactions that generate various critical intermediary metabolites such as glutamate, glutamine, GABA, agmatine, polyamines, creatine, proline , and nitric oxide.”

“Because the substitution of proline , an alpha-imino acid, by arginine may affect the conformation of the whole receptor, the aim of the present study was to determine the pharmacological and functional properties of this variant compared to the wild-type receptor in stably transfected HEK293 cells.”

“Animal studies conducted by Harvey and Gibson showed that simultaneous supplementation with glycine, proline and arginine produced an increase of as much as 60-70% in nitrogen retained.”

“Additionally, flies fed 20 mM l-arginine had higher proline and uric acid concentrations.”

“Dietary supplementation with l-arginine increased plasma concentrations of arginine, ornithine, proline , albumin and reticulocytes, while reducing plasma concentrations of ammonia, free fatty acids, triglyceride, cholesterol, and neutrophils.”

“Supplementation with l-arginine increased plasma concentrations of arginine, ornithine, proline , homoarginine, urea, and nitric oxide metabolites without affecting those for lysine, histidine, or methylarginines, while reducing plasma concentrations of ammonia, glutamine, free fatty acids, and triglycerides.”

“ ARG plus PRO supplementation increased proline and branched-chain amino acid plasma concentrations and improved angiogenesis.”

“Moreover, arginine supplementation increased (P < 0.05) the concentrations of arginine, proline and ornithine in plasma, but concentrations of urea or progesterone in plasma did not differ between the two groups of sows.”

“… Arg to underfed ewes increased (P < … of Arg (69%), ornithine (55%), proline (29%), methionine (37%), leucine (36%), isoleucine (35%), cysteine (19%), and FFA (43%) in maternal serum, decreased maternal circulating levels … (18%) and triglycerides (32%), and enhanced birth weights of lambs by 21% compared with saline-infused underfed ewes.”