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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Pioglitazone
Research Papers that Mention the Interaction
“Acute dose of L-NAME (1 mg/kg, i.p) also … anti-scratching property of pioglitazone (80 mg/kg, p.o); although L-arginine was used in sub-effective dose (100 mg/kg, i.… it potentiated the anti-scratching behavior when co-injected with pioglitazone (20 mg/…, p.o).”
Anti-pruritic activity of pioglitazone on serotonin-induced scratching in mice: possible involvement of PPAR-gamma receptor and nitric oxide.“Acute administration of L-NAME (1, 3 and 10mg/kg) inhibited the anticonvulsant effect … pioglitazone (40 mg/kg), the same result was detected with aminoguanidine (100mg/kg); whereas L-arginine , in the noneffective dose (100mg/kg), potentiated the seizure … when co-administered with a subeffective dose of pioglitazone (20mg/…).”
“ l-Arginine also reversed the antidepressant-like effect of pioglitazone.”
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