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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Physostigmine
Research Papers that Mention the Interaction
“Cholinergic stimulation of the hypothalamic‐pituitary‐adrenal axis and adrenal medulla by physostigmine enhances secretion of arginine vasopressin, epinephrine, and norepinephrine.”
Physostigmine Prevents Postanesthetic Shivering As Does Meperidine or Clonidine“Acute pretreatment with increasing doses of physostigmine markedly affected the blood pressure response to L-arginine (i.e., L-arginine-caused hypotension was more pronounced), but only slightly that to L-NAME.”
“In conclusion, L-arginine , as a donor of NO, produced hypotension by itself and also decreased, but not significantly, the central cholinergically-mediated hypertension (CCMH) produced by physostigmine.”
“ L-arginine and L-NAME depressed the pressor responses to physostigmine , if physostigmine was injected after the end of a 1-hr infusion.”
Physostigmine and modulators of nitric oxide system on the mean arterial pressure of the spontaneously hypertensive rat.“It is concluded that L-arginine-NO pathways act in vivo to oppose peripheral vasoconstrictor influences coupled with central cholinergically mediated activation of the adrenergic system, as produced by physostigmine.”
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