Possible Interaction: Arginine and Phenylephrine

“In seven healthy subjects, we determined the percentage increases in forearm vascular resistance evoked by intra-arterial infusion of phenylephrine at graded doses during simultaneous intra-arterial infusion of saline or arginine vasopressin at two doses.”

“With 1 μM PHE , p-p38/total-p38 MAPK levels at R were markedly increased, indicating its detrimental effect.”

“ L-arginine attenuated PE-induced contraction, and the pD2 value for phenylephrine shifted to the right from -log M 7.10 +/- 0.1 to -6.67 +/- 0.16.”

“Infusion of both phenylephrine and L-arginine increased LDF back to near-baseline levels.”

“Resistance vessel properties were determined by hindquarter perfusion pressure responses to incremental doses of phenylephrine , in the presence of N omega nitro-L-arginine methyl ester (L-NAME) or the L-arginine , the precursor of nitric oxide synthesis.”

“This production of nitric oxide from l‐arginine accounts for the decreased contractility to phenylephrine and the accumulation of cyclic GMP in balloon‐injured arteries.”

“Nitro L-arginine but not calmidazolium reduced the inhibitory influence of the endothelium on the concentration-contraction curves evoked by phenylephrine.”