Possible Interaction: Arginine and Phenylalanine

“Plasma metabolomic studies demonstrated that non-adherent PKU patients had lower circulating concentrations of Tyr, arginine , 2-aminobutyric acid, and propionylcarnitine (q < 0.05, FDR) that were inversely correlated to Phe (r ≈ -0.600 to -0.830).”

“The concentrations of arginine (7.95 vs 5.2 micromol/l), tyrosine (14.3 vs 12.5 micromol/l) and phenylalanine (10.7 vs 9.5 micromol/l) were significantly elevated in neutrophil homogenate from uremic patients before HD and after HD for arginine (8.73 micromol/l).”

“A synergistic effect was exerted by arginine and leucine, arginine and phenylalanine , but not by arginine and lysine, arginine and histidine, or by leucine and histidine.”

“With the addition of arginine , net utilization of threonine, glycine, phenylalanine and branched-chain AA increased (P < 0.05) in Streptococcus sp. and Klebsiella sp., but decreased in E. coli.”

“The depolarization in response toL-phenylalanine andL-arginine was stereoselective, dose-dependent and saturable.”

“The depolarizations induced byL-phenylalanine andL-arginine were significantly additive (p<0.001).”

“At least two NEM-sensitive transporters may be expressed because we have been unable to confirm mutual competitive inhibition between arginine and phenylalanine transport.”

“NEM-sensitive arginine transport is inhibited by leucine, phenylalanine , alanine and valine.”

“Intravenous co‐injection of l‐phenylalanine and arginine vasopressin (30 nmol to 10 pmol) resulted in a decrease of the permeability‐surface area (PaS) product of phenylalanine of between 11 and 39%.”

“However, increasing the arginine concentration in a diet containing 200 g protein/kg increased phenylalanine oxidation, suggesting an amino acid imbalance involving arginine at this lower level of protein.”

“The … of phenylalanine was decreased by the … of proline or arginine to the inadequate protein diet but not by the addition of threonine, methionine, lysine or a mixture of essential … acids, indicating that proline and arginine were limiting the utilization of dietary amino acids in the inadequate protein diet.”

“Both tyrosine and tryptophan, but not phenylalanine , were able to quench the emission of the fluorescent probe by more than 80% upon the addition of arginine.”

“More importantly, they were found to have a profound effect on the luminescence responses to arginine compared with glutamic acid, histidine, tryptophan, threonine, tyrosine and phenylalanine in aqueous environment.”