Possible Interaction: Arginine and Pentamidine

“In order to test this hypothesis, mouse and rat islets were incubated with pentamidine at concentration range of 5×10-…×10-3 mol/1 and exposure times of 3–48 h. The B cell responses to glucose + theophylline and to arginine … pentamidine , while insulin release in … conditions was increased.”

“ Pentamidine caused competitive inhibition of arginine transport, exhibiting an IC50 value of 40 microM. Results indicate the presence of a novel distinct arginine transporter in Leishmania promastigotes.”