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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Plasma arginine and ornithine fluxes increased significantly (P < 0.05) with arginine supplementation, as did the rate of conversion of plasma labeled arginine to ornithine (P < 0.05) and rate of ornithine oxidation (P < 0.001).”
Urea cycle intermediate kinetics and nitrate excretion at normal and "therapeutic" intakes of arginine in humans.“In Experiment 2, L-Arg supplementation increased (P<0.05) arginine and ornithine concentrations compared with urea and control; there was no difference among other amino acids.”
Orally supplemented L-arginine impairs amino acid absorption depending on dose in horses.“ Arginine biosynthesis is intimately linked to the biosynthesis of ornithine , a precursor for siderophore production that has previously been shown to be essential for virulence in A. fumigatus.”
“Substitutions of two arginine residues by ornithine increased the half-lives in full mouse serum from about 20 min to greater than 180 min and the activity.”
“ Arginines are critical for HNP activity, which is decreased by their replacement with ornithine.”
“Amino acid metabolism was stimulated in tumor-bearing animals after receiving 4 or 6% arginine , demonstrated by significant increase of arginine, ornithine , citrulline, proline and histidine levels in the blood (p ≤ 0.001) when compared to the control diet group.”
“AI is also expressed in various extrahepatic tissues and may play a role in regulating arginine levels and in providing ornithine for biosynthetic reactions that generate various critical intermediary metabolites such as glutamate, glutamine, GABA, agmatine, polyamines, creatine, proline, and nitric oxide.”
“It is, therefore, likely that these compounds share the same cellular mechanism of action or that arginine acts via increasing the concentration of available ornithine.”
“The inhibitory effect of ornithine on L-arginine :glycine amidinotransferase (EC 2.1.4.1) was studied in crude rat kidney homogenates.”
“ l-arginine infusion resulted in a larger increase of plasma arginine and ornithine concentrations (p < 0.01), WB (endogenous) arginine appearance (p < 0.001), WB NO synthesis (p = 0.027) and WB arginine to urea conversion (p < 0.001) than infusion of l-alanine.”
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