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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“… L-arginine increased plasma levels of L-arginine …+/-252 micromol/L (P<0.001), L-ornithine from 46+/-8 micromol/L to 2215+/-465 micromol/L (P<0.001), and L-citrulline from … micromol/L (P<0.001), but had no effect on plasma levels of nitrite and nitrate.”
Improvement of cardiac output and liver blood flow and reduction of pulmonary vascular resistance by intravenous infusion of L-arginine during the early reperfusion period in pig liver transplantation.“The effect of low L-lysine diet was amplified by add-on therapy with L-arginine , which we propose to result from competition with L-lysine at system y(+) of the blood-brain barrier and the mitochondrial L-ornithine carriers.”
Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.“Large doses of l-arginine produce a toxic effect on the pancreas, at least in part, through l-ornithine.”
“ l-ornithine levels in the blood were increased 54-fold after intraperitoneal administration of l-arginine.”
“In conclusion, it appears that l-ornithine , produced by arginase from l-arginine in the brain, plays an important role in the sedative and hypnotic effects of l-arginine observed during a stress response.”
“ L-Arginine uptake by IMCD cells was inhibited by the cationic amino acids L-lysine, L-homoarginine, and L-ornithine (10 mmol/l each) and unaffected by the neutral amino acids L-leucine, L-serine, and L-glutamine.”
“The basic amino acids L-lysine and L-ornithine , but not D-arginine or the nitric oxide synthase inhibitors N(G)-nitro-L-arginine methyl-ester and N(G)-nitro-L-arginine, impaired L-arginine uptake.”
“The uptake … mM L-Arg was strongly inhibited by a 20-… of L-lysine (L-Lys) and L-ornithine (L-Orn), but not by D-Arg nor any neutral amino acid, which resembles the … the gamma+ transport system operating in the nerve- and glia cell-, and synaptic plasma membranes.”
“L-Lysine (10 mM) and L-ornithine (10-30 mM) slightly increased contraction and caused a rightward shift in concentration-relaxation curves in response to L-arginine.”
“The Km … for L-arginine was … L-ornithine inhibited the reaction competitively with a Ki of 985 +/- 105 microM. D-Ornithine was a weak inhibitor with a Ki of … polyamines putrescine and spermidine inhibited ADI incompetitively with a Kii of 2.8mM for putrescine and 4.3mM for spermidine.”
“The kcat/Km for l-arginine is 550-fold higher than for either l-ornithine or l-lysine, which were decarboxylated with similar efficiency.”
Paramecium bursaria Chlorella Virus-1 Encodes an Unusual Arginine Decarboxylase That Is a Close Homolog of Eukaryotic Ornithine Decarboxylases*
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