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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Arginine
Research Papers that Mention the Interaction
“Infusion of L‐NMMA resulted in a maximum venodilation of 38% ± 11% ( R ) versus 10% ± 5% (NR; P = .005).”
Characterization of Local Vascular Effects of the Nitric Oxide Inhibitor NG‐Monomethyl‐L‐Arginine on Dorsal Hand Veins“The prolonged effect of L-NMMA and L-arginine must be taken into account in study protocols using both substances.”
“All hemodynamic effects of L-NMMA were reversed by L-arginine.”
“ L-Arginine (10(-3) mol/L) prevented the contractions by L-NMMA and ADMA but did not change contractions induced by AG and MG.”
“The coinfusion with L-arginine caused a nearly two-fold increase in plasma L-NMMA levels, indicating a pharmacokinetic interaction.”
“The mean BP significantly increased during infusion of L-NMMA (control 97.0 +/- 5.7 vs. L-NMMA 4.0 mumol/min: 116.4 +/- 3.1 mm Hg) and this was also reversed by L-arg.”
“ L-Arginine alone failed to affect basal or stimulated (CCK or yolk) emptying of the GB, but when combined with L-NMMA , it reversed the enhancement of GB contraction caused by L-NMMA.”
“When added at the apical side, the NOS‐inhibitors NMMA and NIL, CAA analogs with a free carboxyl group, markedly inhibited the apical arginine influx and the transepithelial flux of the cationic amino acid.”
“Pretreatment with l‐NMMA caused a prompt drop in myeloperoxidase (MPO) activity, suggesting rapid adhesion of PMNL to the coronary wall; this effect was significantly blunted by l‐arginine.”
“Pretreatment with l‐NMMA , caused a marked rise in cys‐LT concentrations which was prevented by l‐arginine.”
“… NG‐monomethyl‐l‐arginine , 10 μm (l‐NMMA), induced a marked increase in CPP (290±40 mmHg, at 20 min) and in … it caused cardiac arrest in systole in 5 out of 6 hearts and these were prevented by l‐arginine , 100 μm (CPP 115±… mmHg, at 30 min).”
“Furthermore, l‐NMMA also reversed the dilatation already induced by PACAP and excess concentrations of l‐arginine restored the dilator response of the l‐NMMA treated arteries.”
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