Possible Interaction: Arginine and Norepinephrine

“Full concentration-response curves to norepinephrine (…- or D-ARG 10 microM. Both L-ARG [-log EC50 (M) before vs. after arginine 7.12 +/- 0.15 vs. 6.66 +/- 0.16, Student'… vs. 6.85 +/- 0.18; Student's paired t test, p < 0.05] significantly antagonized responses to NE ….”

“In addition, central NA mechanisms are thought to modulate the behavioural effects of peptides such as arginine vasopressin, which has been used to treat human memory disorders (Kovacs et al. 1979).”

“In HuH-7.MCAT-1 cells l-arginine uptake was significantly up-regulated by norepinephrine and dexamethasone, and hepatocyte growth factor also increased l-arginine uptake along with cellular DNA synthesis.”

“ Arg and Agm plus Arg decreased secretion of dopamine and norepinephrine by oTr1 cells.”

“Adrenaline and noradrenaline (and not isoproterenol) also reduced vessel tension in the presence of L-Arginine.”

“Myocardial tyrosine hydroxylase protein was decreased in SHR following l-arginine supplementation, providing a link to reduced synthesis of norepinephrine.”

“In addition, we found that simultaneous administration of norepinephrine or vasopressin with l-arginine improved all microcirculation variables more efficiently than either vasopressor alone.”

“Potentiated contractile response to 1 mM ATP in the presence of 10 microM NA was further potentiated by the treatment with 1 mM L-ARG , while the response was almost unaffected by the treatment with 0.1 mM L-NNA.”

“In contrast, substitution with arginine reduced NE flux below that expected for the size of its side chain.”

“ l-Arginine markedly attenuated or prevented these changes and also normalized the reduced efficacy of norepinephrine and acetylcholine in isolated thoracic aortic rings of DOCA-salt hypertensive rats.”