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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Arginine
drug:
Nitroprusside
Research Papers that Mention the Interaction
“Under inflammatory conditions, l-arginine as well as a NO donor (sodium nitroprusside ( SNP )) increased NO production, which was inversely correlated with IL-8 production (r'=-0.66, P=0.007 for arginine; r'=-0.79, P<0.0001 for SNP).”
L-Arginine modulates CXC chemokines in the human intestinal epithelial cell line HCT-8 by the NO pathway.“ l-arginine treatment in vitro reduced basal apoptotic rates and prevented apoptosis in response to mechanical strain, an effect enhanced by SNP co-incubation.”
Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy“In addition, MnSOD and L-arg decreased the relaxing effect of SNP on the isolated ileum of the guinea pig.”
“The results show that …) and 10 microM L-arginine (… SNP induced relaxations (6-55%; p < 0.05, p < 0.001 and 2-46%; p < 0.05, p < 0.01 for … < 0.01, p < 0.001 and 12-32%; p < 0.05, p < 0.01 for Ach-induced contractions, respectively).”
“The LPSinduced arginine transport activity was blocked by sodium nitroprusside (SNP) (control: 25 ±6; LPS: 97 ±26*; SNP: 22 ±0.4+; LPS+SNP: 33 ±10.3+ pmole/mg/min, *P < 0.01 and +p = NS, compared with control).”
“Concomitant treatment with SNP and L-Arg significantly reduced the serum creatinine and BUN levels, reduced lipid peroxidation in a significant manner, restored levels of reduced glutathione, increased total nitric oxide levels and restored the normal morphology.”
“Pretreatment with SNP and L-Arg attenuated the levels of TNF-alpha in serum in a significant manner.”
“ L-arg antagonized the … effect of SNP in the examined renal arteries, more in normotensive (100-160% with endothelium and 110-195% without) than in hypertensive ones (0-…% with endothelium and 35-75% without) at SNP concentrations 10(-7) - 10(-5) M, respectively (*P < 0.05; **P < 0.001).”
“It is shown that intracoronary infusion of L-arginine and sodium nitroprusside induces an increase in coronary flow (CF), myocardial contractility (MC) and heart rate (HR) in the isolated perfused heart of the rat.”
“On the other hand, the NO donor sodium nitroprusside SNP ) was able to mimic the excitatory effect of L-arginine.”
“was enhanced by co-administration of sodium nitroprusside (0.25 mg/kg), and L-arginine (50 mg/kg).”
“ L-arginine failed to attenuate the endotoxin-induced dysfunction of the response to SNP.”
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