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Last Updated: 2 years ago

Possible Interaction: Arginine and Nicotine

supplement:

Arginine

Research Papers that Mention the Interaction

Significant inhibition of arginine transport was detected with nicotine (P =.007), cocaine (P =.01), and their combination (P =.01), whereas phenylalanine (P =.03, P =.04) and valine (P =.03, P =.04) transport was affected by cocaine and the combination of cocaine and nicotine, respectively.
The Journal of pharmacology and experimental therapeutics  •  2000  |  View Paper
Conversely, coinjection of a subeffective dose of L-arginine with the subeffective dose of nicotine significantly boosted its protective effects.
Conversely, coinjection of a subeffective dose of l-arginine with the subeffective dose of nicotine significantly boosted its protective effects.
Annals of plastic surgery  •  2019  |  View Paper
Interestingly, the inhibitory effect of L-NAME and the potentiating effect of l-arginine on nicotine response were associated with the decrease and increase of the PFC p-CREB/CREB ratio respectively.
Neurobiology of Learning and Memory  •  2019  |  View Paper
Similarly Intracerebroventricular injection of l‐arginine (25–100&mgr;g/rat), a biosynthetic precursor of agmatine and arcaine (50&mgr;g −100&mgr;g/rat), an agmatinase inhibitor, also increased the step through latency during retrieval test in nicotine withdrawn animals.
Pharmacology Biochemistry and Behavior  •  2018  |  View Paper
Findings that favor the involvement of NOS inhibition in the nicotine effect were (i) NOS inhibition (N ω-Nitro-L-… methyl ester, L-NAME) reduced BRS in control rats but failed to do so in nicotine-treated rats, (ii) L-arginine , NO donor, reversed the … inhibitory effect of nicotine.
PloS one  •  2014  |  View Paper
Interestingly, an ineffective dose of nicotine (0.2 μg/mouse) in combination with a low dose of L-arginine (0.8 μg/mouse) synergistically improved memory performance impaired by ethanol given before training.
Neuroscience  •  2012  |  View Paper
On the other hand, injection of the low dose nicotine before different doses of l-arginine or l-NAME blocked the anxiogenic-like response induced by the drugs.
Neuroscience Letters  •  2012  |  View Paper
However, a decrease in arginine microdialysate content was still observed with all nicotine doses.
Brain Research  •  2006  |  View Paper
injections of nicotine (0.15-0.3-0.6 mg/kg), significantly increased aspartate, glutamate, arginine , taurine, and alanine microdialysate content in the nucleus accumbens.
European Neuropsychopharmacology  •  2005  |  View Paper
We found that topical application of L-arginine to cerebral microvessels during infusion of nicotine could prevent impaired NOS-dependent vasodilatation.
We suggest that exogenous L-arginine may have a beneficial role in preventing cerebral microvascular dysfunction during exposure to nicotine.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco  •  2004  |  View Paper
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