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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Significant inhibition of arginine transport was detected with nicotine (P =.007), cocaine (P =.01), and their combination (P =.01), whereas phenylalanine (P =.03, P =.04) and valine (P =.03, P =.04) transport was affected by cocaine and the combination of cocaine and nicotine, respectively.”
The effects of cocaine and nicotine on amino acid transport across the human placental cotyledon perfused in vitro.“Conversely, coinjection of a subeffective dose of L-arginine with the subeffective dose of nicotine significantly boosted its protective effects.”
“Conversely, coinjection of a subeffective dose of l-arginine with the subeffective dose of nicotine significantly boosted its protective effects.”
Acute Activation of α7-Nicotinic Receptors by Nicotine Improves Rodent Skin Flap Survival Through Nitrergic System.“Interestingly, the inhibitory effect of L-NAME and the potentiating effect of l-arginine on nicotine response were associated with the decrease and increase of the PFC p-CREB/CREB ratio respectively.”
“Similarly Intracerebroventricular injection of l‐arginine (25–100&mgr;g/rat), a biosynthetic precursor of agmatine and arcaine (50&mgr;g −100&mgr;g/rat), an agmatinase inhibitor, also increased the step through latency during retrieval test in nicotine withdrawn animals.”
“Findings that favor the involvement of NOS inhibition in the nicotine effect were (i) NOS inhibition (N ω-Nitro-L-… methyl ester, L-NAME) reduced BRS in control rats but failed to do so in nicotine-treated rats, (ii) L-arginine , NO donor, reversed the … inhibitory effect of nicotine.”
“Interestingly, an ineffective dose of nicotine (0.2 μg/mouse) in combination with a low dose of L-arginine (0.8 μg/mouse) synergistically improved memory performance impaired by ethanol given before training.”
“On the other hand, injection of the low dose nicotine before different doses of l-arginine or l-NAME blocked the anxiogenic-like response induced by the drugs.”
“However, a decrease in arginine microdialysate content was still observed with all nicotine doses.”
“injections of nicotine (0.15-0.3-0.6 mg/kg), significantly increased aspartate, glutamate, arginine , taurine, and alanine microdialysate content in the nucleus accumbens.”
“We found that topical application of L-arginine to cerebral microvessels during infusion of nicotine could prevent impaired NOS-dependent vasodilatation.”
“We suggest that exogenous L-arginine may have a beneficial role in preventing cerebral microvascular dysfunction during exposure to nicotine.”
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