Pentadecapeptide BPC 157 shortens duration of tetracaine- and oxybuprocaine-induced corneal anesthesia in rats

 were applied together, they antagonized each other’s effect.

Arginine Attenuates Methylglyoxal- and High Glucose-Induced Endothelial Dysfunction and Oxidative Stress by an Endothelial Nitric-Oxide Synthase-Independent Mechanism

However, the inhibitory effect of the NOS inhibitor

The influence of gastric pentadecapeptide BPC 157 on acute and chronic ethanol administration in mice. The effect of N(G)-nitro-L-arginine methyl ester and L-arginine.

 counteract each other, while either the "L-NAME presentation" (acute intoxication) or the "L-arginine presentation" (withdrawal) predominates.

Nitric oxide stimulates insulin release in liver cells expressing human insulin.

The arginine-induced insulin release is via the production of nitric oxide, since treatment with

, an inhibitor of nitric oxide synthase, blocks insulin secretion induced by 

Characterization and cardiovascular actions of endothelin-1 and endothelin-3 from the American alligator.

, indicating that the effect of the peptide is probably not mediated through increased synthesis of nitric oxide.

Can L-arginine manipulation reduce renal disease?

Administration on a chronic basis of N-nitro-L-arginine methylester 

, increases blood pressure and reduces the ultrafiltration coefficient.

Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart.

[Nitric oxide as a regulatory factor in sleep-wakefulness mechanisms].

Induction of smooth muscle cell nitric oxide synthase by human leukaemia inhibitory factor: effects in vitro and in vivo.

 was ameliorated by co-administration of 

The inhibitory role of nitric oxide in the control of porcine and human sphincter of Oddi activity

Effects of nitric oxide on human and canine prostates.

Nitric oxide regulation of glycoconjugate secretion from feline and human airways in vitro.

 in both MCh- and BK-induced secretions from isolated glands.

Cardiovascular effects of L-arginine as physiological precursor of nitric oxide.

Selective inhibition of NO-synthetise with

 and intensified the vasoconstrictor effect of phenylephrine.

Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism.

The nitric oxide synthase (NO synthase, EC 1.…) inhibitors NG-monomethyl-L-arginine (L-NMMA) and

 (L-NAME) both inhibited the production of angiogenic …-stimulated M phi in the presence of 

, suggesting the involvement of this … pathway that generates angiogenic activity.

Techniques to harvest diseased human peripheral arteries and measure endothelial function in an ex vivo model.

 abrogated EDR (P < .0001) in vessels exposed to 

Combined effects of arginine and hydroxyurea on BFU-E derived colony growth and HbF synthesis in erythroid progenitors isolated from sickle cell blood.

 (L-NAME; 100μM), a nitric oxide synthase inhibitor, attenuated the effects of 

 on HbF synthesis compared to HU and HU+arginine controls.

Effect of anion channel blockers on l‐arginine action in spermatozoa from asthenospermic men

 was neutralised on adding an NO‐synthase inhibitor like 

L-arginine attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells.

The PI3K inhibitor LY294002 or eNOS inhibitor

Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells.

Blockade of l-arginine uptake by l-lysine inhibited NOS activity and, conversely, blockade of NOS using

Nitric Oxide Regulates the Phosphorylation of the Threonine-Glutamine-Tyrosine Motif in Proteins of Human Spermatozoa During Capacitation1

 for nitric oxide synthase) prevented, and a nitric oxide donor promoted, the increase in P-Thr-Glu-Tyr-P related to sperm capacitation.

 on capacitation and the associated increase of P-Thr-Glu-Tyr-P. Therefore, the regulation of P-Thr-Glu-Tyr-P is specific to nitric oxide and not to superoxide anion or hydrogen peroxide.

Nitric Oxide Synthesis Enhances Human Immunodeficiency Virus Replication in Primary Human Macrophages

, confirming that an arginine-dependent mechanism is involved.

Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells.

Concomitantly, in comparison to either the control or the oxygenated sample, there is a significant and steady increase of nitric oxide (NO) production; this is markedly enhanced by the addition of

 (20 microM) and inhibited in the presence of the NO inhibitor, 

Nitric oxide stimulates cyclic guanosine monophosphate production and electrogenic secretion in Caco-2 colonocytes.

 (Nomega-nitro-L-arginine methyl ester, 1 mM), but not the D-isomer, significantly reduced the electrogenic secretion and cGMP production evoked by 

, implicating nitric oxide synthase involvement.

Theophylline inhibits the production of nitric oxide by peripheral blood mononuclear cells from patients with asthma.

 significantly reduced NO production in asthmatics (0.83+/-0.06 microM; P < .05), an effect completely reversed by 

ZR-75-1 human breast cancer cells: expression of inducible nitric oxide synthase and effect of tamoxifen and phorbol ester on nitric oxide production.

ZR-75-1 cells spontaneously produced nitric oxide (NO) and this production could be significantly (P < 0.001) enhanced by

Regulation of P-selectin expression in human endothelial cells by nitric oxide.

A thromboelastography study on the in vitro effects of L‐arginine and L-NG-nitro arginine methyl ester on human whole blood coagulation and fibrinolysis

 and K and increased α, MA and the TEG index in a concentration-dependent manner.

MA (clot strength) involves the integrity of fibrin strands and platelet aggregation, and again

Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.

 (L-NAME; 200 microM), an inhibitor of NO synthase, and this was reversed by 

Influence of endothelial nitric oxide on neurogenic contraction of human pulmonary arteries.

 (10(-4) M) but not by D-arginine (10(-4) M).

Nitric oxide regulates the chemiluminescence from stimulated human neutrophils

 increased the chemiluminescence after stimulation with any of the three stimuli, while 

Nitric oxide release from resting human platelets.

The release of nitric oxide was stimulated by

Nitroxidergic nerve stimulation relaxes human uterine vein.

Release of nitric oxide by nerve stimulation in the human urogenital tract.

Relaxations induced by nerve stimulation were inhibited by N omega-nitro-L-arginine methyl ester 

Endothelium-dependent component in the contractile responses of human omental arteries to adrenergic stimulation.

 (10(-4) M), but not by D-arginine (10(-4) M).

Nitric oxide blockade in mediodorsal thalamus impaired nicotine/ethanol-induced memory retrieval in rats via inhibition of prefrontal cortical pCREB/CREB signaling pathway

 (0.05, 0.1 and 0.3 μg/rat) reversed the 

Therapy of the rat hemorrhagic cystitis induced by cyclophosphamide. Stable gastric pentadecapeptide BPC 157, L-arginine, L-NAME.

 aggravated these lesions and eradicated beneficial effect of 

Anti-nociceptive mechanisms of flavonoids-rich methanolic extract from Terminalia coriacea (Roxb.) Wight & Arn. leaves.

Treatment of TCLME alone and in combination with

 (100 mg/kg, i.p) significantly (p < 0.001) reduced writhing while pre-treatment with 

 (20 mg/kg, i.p) further enhanced the analgesic action of TCLME indicating involvement of nitric oxide pathway.

L-arginine and Arginase Products Potentiate Dexmedetomidine-induced Contractions in the Rat Aorta

 augmented the dexmedetomidine-induced contractions in the presence of 

L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells

, an NOS inhibitor, decreased NO concentrations within cells and abolished the stimulatory effect of 

 on protein synthesis and the phosphorylation of mTOR and p70S6K.

Cyclophosphamide induced stomach and duodenal lesions as a NO-system disturbance in rats: l-NAME, l-arginine, stable gastric pentadecapeptide BPC 157

This suggests that in cyclophosphamide damaged rats, NO excessive release generated by the inducible isozyme, damages the vascular wall and other tissue cells, especially in combination with reactive oxygen intermediates, while failing endothelial production and resulting in further aggravation by

Heat shock protein 70/nitric oxide effect on stretched tubular epithelial cells linked to WT-1 cytoprotection during neonatal obstructive nephropathy

 increased apoptosis and prevented the anti-apoptotic action of 

Nitric oxide reduces paracellular resistance in rat thick ascending limbs by increasing Na+ and Cl- permeabilities.

 effect on Rt Next we tested the effect of cGMP.

Nitric Oxide–Mediated Regulation of GLUT by T3 and Follicle-Stimulating Hormone in Rat Granulosa Cells

 upregulated GLUT-1/GLUT-4 expression and translocation, which were related to increased glucose uptake; however, these responses were significantly blocked by 

Protective effect of spermine against pentylenetetrazole kindling epilepsy induced comorbidities in mice

The role of nitric oxide pathway in arginine transport and growth of IPEC-1 cells

Taken together, these data suggest that inhibition of NO pathway by

 induces a negative feedback increasing of 

 uptake and CAT-2 and y+LAT-1 protein expression, but promotes cell apoptosis which involved inhibiting the activation of mTOR and PI3K-Akt pathways.

Addition of L-arginine to the fertilization medium enhances subsequent bovine embryo development rates.

Although both ARG and HEP increased sperm NO production (P < 0.05), combination with

 only precluded acrosomal exocytosis when 

Evidence for the involvement of nitric oxide in cholestasis-induced itch associated response in mice.

 and AG were reversed by pretreatment with 

Nitric Oxide Overproduction Reduces Insulin Secretion from Isolated Islets in Fetal Hypothyroid Rats.

 significantly improved insulin secretion in fetal hypothyroid rats at basal glucose concentration and in the presence of 

NO system dependence of atropine-induced mydriasis and L-NAME- and L-arginine-induced miosis: Reversal by the pentadecapeptide BPC 157 in rats and guinea pigs.

 were combined (L-NAME+L-arginine+BPC 157), the effect was less pronounced.

Role of NO-cGMP pathway in ovine cervical relaxation induced by Erythroxylum caatingae Plowman.

 on cervical relaxation caused by Ec-EtOH.

Antinociceptive and anti-inflammatory effects of myricetin 3-O-β-galactoside isolated from Davilla elliptica: involvement of the nitrergic system

 (but not d-Arg) reversed the antinociceptive effect of 

Mature coconut water exhibits antidiabetic and antithrombotic potential via L-arginine-nitric oxide pathway in alloxan induced diabetic rats

MCW and L-arginine treatment prolonged the prothrombin time in diabetic rats and reduced the activity of Factor V. In addition … of nitric oxide synthase, liver and plasma arginine content, and urinary nitrite were higher in MCW-treated diabetic rats whereas

Modulation of opioid-induced feeding behavior by endogenous nitric oxide in neonatal layer-type chicks

On the other hand, the co-injection of 100 nmol

 significantly attenuated the anorexigenic effect of 800 nmol 

Anti-hyperalgesic effect of systemic magnesium sulfate in carrageenan-induced inflammatory pain in rats: influence of the nitric oxide pathway.

 (0.4 mg/kg, subcutaneously) significantly reversed the effect of 

Arginine NO-dependent and NO-independent effects on hemodynamics.

 significantly decreased MABP and SVR at the highest dose while d-arginine failed to do so.

[Inhibitory effect of nitric oxide-induced total ginsenosides on right ventricular hypertrophy in rats].

 on above indexes, whereas L-NAME of the same dose could not impact the reducing effect of TG 40 mg kg -1 on above indexes.

Anti-inflammatory activity of the hexane extract of Byrsonima crassifolia seeds in experimental animal models.

, a precursor of NO, significantly inhibited the anti-inflammatory effects of NS and 

, an anti-inflammatory drug, on mouse paw edema, but D-arginine did not.

Hypertonicity increases NO production to modulate the firing rate of magnocellular neurons of the supraoptic nucleus of rats

 hyperpolarizes the resting potential and decreases the peak value of the after-hyperpolarization; both effects were blocked by 

 and hypertonicity and/or L-NAME reduced the time constant of the rising phase of the after-depolarization.

Involvement of opioidergic and nitrergic systems in memory acquisition and exploratory behaviors in cholestatic mice

 and naloxone exerted no effect on memory acquisition in the 7 days post-BDL mice, 

 (100 and 200 mg/kg) and morphine (2.5, 5, and 7.5 mg/kg) injection reduced it.

Nitric oxide modulates bladder afferent nerve activity in the in vitro urinary bladder–pelvic nerve preparation from rats with cyclophosphamide induced cystitis

Nitric oxide regulates cardiac intracellular Na+ and Ca2 + by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism☆

Arrhythmia incidence was significantly increased in rat hearts paced in the presence of

), as well as in PLM3SA mouse hearts but not PLMWT and PLMKO.

Arginine induces GH gene expression by activating NOS/NO signaling in rat isolated hemi-pituitaries

The NO acceptor hemoglobin (0.3 µM) blunted the effect of SNP, and the combined treatment with

 (an NO synthase (NOS) inhibitor, 55 mM) abolished the stimulatory effect of Arg on GH gene expression.

Nitric oxide in the hippocampal cortical area interacts with naloxone in inducing pain

 was blocked by pre-microinjection (1–2 min) of 

 (0.15, 0.3, 1.0, and 3.0 μg/rat), whilst, L-arginine or L-NAME alone did not induce pain behavior.

Effect of a Blocker of Nitric Oxide Production on Albumin Excretion by Rat Kidney

The degree of proteinuria and albuminuria increased in combined treatment with

Effects of honey on inflammation and nitric oxide production in Wistar rats.

 significantly inhibited paw oedema while the administration of 

 abolished the anti-inflammatory effect of honey and L-NAME.

In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata

 reduced the paw edema (60–120 min) elicited by 

Involvement of vascular endothelial nitric oxide synthase in development of experimental diabetic nephropathy in rats

, a eNOS inhibitor, significantly attenuated the 

, daidzein-, or combination of l-arginine and daidzein-induced ameliorative effects in DN.

Microinjection of l-arginine into corpus callosum cause reduction in myelin concentration and neuroinflammation

Role of alpha adrenoceptors and nitric oxide on cardiovascular responses in acute and chronic hypertension

 was larger in all groups compared without l-NAME and in presence of 

The influence of short-term l-arginine supplementation on rats’ muscular and hepatic cells in ischemia–reperfusion syndrome

 resulted in a reversal of changes induced by l-arginine supplementation in the case of AspAT and free radicals in skeletal muscle.

Effects of L-nitro-arginine methyl ester, an inhibitor of nitric oxide biosynthesis, on intestinal ischemia/reperfusion injury in rabbits.

 attenuated intestinal dysfunction caused by 

Role of nitric oxide in ginsenoside Rg(1)-induced protection against left ventricular hypertrophy produced by abdominal aorta coarctation in rats.

Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception

It should be noted that a single injection of both

 showed nociceptive effect at the early phase of the test.

Vasorelaxant Action of N-p-Nitrophenylmaleimide in the Isolated Rat Mesenteric Artery

 (1 mM) reversed the inhibitory effect of 

Impairment of endothelium-dependent vasorelaxation in cadmium-hypertensive rats

 (L-Arg, 10 —3 M) caused a similar reversal of the inhibition of ACh-induced relaxation by 

Influence of L-arginine on the nitric oxide concentration and level of oxidative stress during ischemia-reperfusion injury in a rat model.

L-arginine-induced dilatation of goat coronary artery involves activation of K(ATP) channels.

, L-NNA and L-NMMA and the guanylyl cyclase inhibitor, methylene blue failed to attenuate the relaxant response of 

Nitric oxide reduces flow-induced superoxide production via cGMP-dependent protein kinase in thick ascending limbs.

The addition of the NO synthase inhibitor

 stimulated production (L-arginine: 15 +/- 4 AU/s vs. L-arginine + L-NAME: 63 +/- 7 AU/s; P < 0.002).

The role of hippocampal nitric oxide (NO) on learning and immediate, short- and long-term memory retrieval in inhibitory avoidance task in male adult rats

 produced no any significant effect on STL, however could reverse the effect of 

Activation of neuronal nitric oxide release inhibits spontaneous firing in adult gonadotropin-releasing hormone neurons: a possible local synchronizing signal.

 were prevented by the NO synthase inhibitor 

N omega-nitro-L-Arg methyl ester hydrochloride.

Polyaspartoyl.L-arginine enhances prostacyclin synthesis in rat aortic endothelial cells.

Interestingly PDR (1.70-500 microg/ml), L-arginine (17.0-170 microg/ml) significantly elevated PGI(2) … in medium of RAECs (P<0.01), NO synthase inhibitor, N(G)-nitro L-arginine methyl ester 

), markedly inhibited the elevated PGI(2) levels by PDR and 

Protective effect of nitric oxide synthase inhibition or antioxidants on brain oxidative damage caused by intracerebroventricular arginine administration

Furthermore, intracerebroventricular infusion of

 on Na(+),K(+)-ATPase activity, as well as the increased of TBA-RS.

Roles of nitric oxide (NO) and NO synthases in healing of dextran sulfate sodium-induced rat colitis.

The healing of DSS-induced colonic lesions was significantly impaired by daily administration of L-NAME or aminoguanidine, the effects being all but equivalent between these drugs, and the effect of

 was significantly reverted by the co-administration of 

The involvement of prostaglandins and nitric oxide in the development of brain excitability: a relationship study.

 on S&W of mice was dose-dependently reversed by 

Tuning adenosine A1 and A2A receptors activation mediates l-citrulline-induced inhibition of [3H]-acetylcholine release depending on nerve stimulation pattern

Inhibition of CO2 production from glucose by arginine in brain slices of rats

 administration inhibited CO2 production from glucose at physiological extracellular K+ concentration and 

Intracerebroventricular injection of l-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks

 were slightly attenuated by the inactive isomer of the NOS inhibitor 

Prevention of pro-depressant effect of L-arginine in the forced swim test by NG-nitro-L-arginine and [1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one].

, the antidepressant and pro-depressant effects of 

 disappeared, however, only the pro-depressant component of l-arginine effect was prevented by ODQ (3 and 10 mg/kg).

Role of nitric oxide in the vasorelaxant and hypotensive effects of extracts and purified tannins from Geum japonicum.

, the substrate for NO biosynthesis, reversed the inhibitory effects of 

The Role of Nitric Oxide in the Neuroprotection of Limb Ischemic Preconditioning in Rats

Three-dimensional growth of endothelial cells in the microgravity-based rotating wall vessel bioreactor

 to the RWV cultures resulted in a fourfold increase in NO production over untreated RWV cultures, which was completely blocked by 

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Possible Interaction: Arginine and Ng-Nitroarginine Methyl Ester

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Research Papers that Mention the Interaction