Possible Interaction: Arginine and Melatonin

“While the antinociceptive effect of melatonin was increased by l-arginine , SNAP, and sildenafil, it was significantly reduced by l-NAME and glibenclamide in both phases of the formalin test, with no relation to the sedative effects of melatonin evaluated by the inclined plane test.”

“The use of melatonin alone or in combination with erythropoietin, sodium hydrosulfide or L-arginine led to a decrease in lipid peroxidation products and an increase in the antioxidant protection.”

“Indeed, melatonin reduced macrophage arginine uptake by 40%.”

“ Melatonin modulates arginine vasotocin (AVT)‐immunoreactive (‐IR) cell number in the brain of green treefrogs (Hyla cinerea) during the summer breeding season, and this modulation is sexually dimorphic.”

“ Melatonin additionally increased L-arginine concentrations in BDL liver, which is correlated with decreased PKC-α translocation.”

“We recently found that L-arginine levels were significantly raised by melatonin in young rats with BDL.”

“However, L-arginine (100 mg/kg) pretreatment with melatonin (2.5 mg/kg, ip) significantly reversed its protective effects.”

“Administration of both l-arginine and naloxone, at doses which produced no effect on their own, partially reversed antihyperalgesic effect of melatonin.”

“Elevation of the serum amylase level was significantly reduced in rats given melatonin following L-Arg compared to rats injected with L-Arg only.”

“ Melatonin given in advance of L-Arg significantly reduced the pancreatic CAT activity relative to that in the rats treated with L-Arg alone.”

“We did not observe an augmentation in the contractility of ileum when we use melatonin and l‐arginine in combination, in fact, melatonin decreased the protective effect of l‐arginine in intestinal I/R injury.”

“ Melatonin inhibited neuronal excitation produced by either NMDA or l‐arginine.”