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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Arginine
drug:
Mecamylamine
Research Papers that Mention the Interaction
“Isobolographic analysis exhibited an additive antidepressant effect of the combined subthreshold doses of mecamylamine and L-arginine , and a synergistic antidepressant effect of the combined subthreshold doses of mecamylamine and L-NAME.”
Better antidepressant efficacy of mecamylamine in combination with L-NAME than with L-arginine“Coadministration of the subeffective dose of mecamylamine together with the lower doses of L-NAME (10 and 30 ng/0.5 &mgr;l, bilaterally) or L-arginine (0.5 &mgr;g/0.5 &mgr;l, bilaterally) led to a decrease in %OAT and %OAE.”
“Nicotine injection (0.25, 0.5 and 0.75 mg/kg) … the expression of place preference induced by L-arginine, while both mecamylamine (0.05 and 0.1 mg/kg) and L-NAME (5, 10 … the acquisition of place preference induced by nicotine (1 mg/kg) and L-arginine (…).”
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