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“The enzyme activity could be increased by the addition of manganese ions, and the inhibitory effect on cell proliferation could be reversed by additional arginine.”
Biological Trace Element Research • 2007 | View Paper
“Our results suggest that ammonia and manganese may contribute to the pathogenesis of HE by influencing arginine transport and thus possibly NO synthesis in astrocytes.”
“These results suggest that both manganese and ammonia alter L-arginine uptake by modifying the transporter for arginine.”
“When cultures were treated separately with 5 mM ammonia and 100 μM manganese for 2 days, the uptake of L-arginine increased by 41% and 57%, respectively.”
“In an in vitro study, MnSOD mRNA expression peaked at 2 hours after the addition of arginine to culture medium, whereas apoptosis was increased at 24 hours.”
“Both purified arginase and arginase-containing H. pylori extracts exhibited optimal catalytic activity with cobalt as a metal cofactor; manganese and nickel were significantly less efficient in catalyzing the hydrolysis of arginine.”