Possible Interaction: Arginine and Lysine

“Results of the present study support the hypothesis that L-lysine in combination with L-arginine , which may induce anxiolytic effects, modify hormonal responses during psychosocial stress in humans.”

“ Arginine stimulates GH release, and lysine may amplify this response.”

“Inhibition of L-Arg uptake with the competitive inhibitor, L-lysine (L-Lys), also prevented attachment of C. rodentium and chemokine expression.”

“Replacement of arginines with lysines reduced the uptake of the conjugate by six-fold, resulting in the abolition of intracellular target inhibition.”

“Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines … 315, which is important for the ubiquitination and degradation of chromatin-associated RelA. Abolishing the acetylation of lysine 310 either by the deacetylase SIRT1 … by mutating lysine 310 to arginine enhances ….”

“An intravenous administration of a mixture of 10 mM L-arginine and L-lysine decreased splenic sympathetic nerve activity (splenic-SNA).”

“Substitution of these lysines by arginines in TRalpha decreased ligand binding affinity and precluded ligand-dependent release of corepressors and recruitment of coactivators.”

“ Arginine mutation of the three lysines results in a significant reduction of transcriptional repression activity.”

“Our finding is the first report that substitution of a key RelA lysine residue with arginine inhibits TNFα-induced RelA ubiquitination and enhances TNFα-induced NF-κB activation.”

“Conversion of this lysine to an arginine (K51R) substantially reduced Nkx2.5 DNA binding and also its transcriptional activity.”