Possible Interaction: Arginine and Leucine

“Among branched-chain amino acids, l-leucine is unique in inhibiting NO synthesis from l-arginine in endothelial cells and may modulate cardiovascular homeostasis in insulin resistance.”

“Moreover, in Xenopus oocytes coexpressing 4F2hc and y+LAT2, leucine exerts a marked inhibition of arginine transport, partially dependent on sodium, while no inhibition is seen in oocytes expressing CAT1.”

“This combination of R and L genotypes was associated with lower PON1 activity towards diazoxon in both cases and controls.”

“ Arginine uptake was inhibited strongly by lysine, glutamate, leucine , glutamine, methionine and histidine.”

“Similarly, the basal and 4F2hc cRNA-stimulated sodium-dependent uptake of L-leucine is entirely inhibited by L-arginine. (”

“ii) Basal and 4F2hc cRNA-stimulated sodium-independent uptake of L-arginine is completely inhibited by L-leucine in the presence of sodium.”

“It has been established that L argi nine use contributed to increasing the content of serum arginine , nitrite, nitrate, and amounts of NO metabolites in children with endothelial dysfunction.”

“These results indicate that the combination of T + L + R induces a significantly enhanced antigen presentation effect of AML-DC.”

“There was a strong trend (P = 0.08) toward a greater reduction in leucine incorporation into protein after R compared to E(2) cotreatment.”

“Under all the conditions tested, leucine inhibits most of the arginine transport in the presence of Na+ and N-ethylmaleimide, an inhibitor of system y+, is completely ineffective, indicating that system y+L operates most of the arginine influx.”

“ Leucine at position 55 and arginine at position 192 have been associated with increased cardiovascular risk.”