Possible Interaction: Arginine and Leptin

“This together with an almost two-fold elevated plasma arginine level in Pept1−/− but not wildtype mice, suggests that a cross-talk of arginine with leptin signaling in brain, as described previously, could cause these striking effects on food intake.”

“In obese mice, a 2.5-fold increase in leptin concentration coincided with 100% increase in eNOS and about 30% decrease in intracellular L-arginine.”

“In obesity, leptin increases eNOS expression and decreases intracellular l-arginine , resulting in eNOS an uncoupling and depletion of endothelial NO and an increase of cytotoxic ONOO(-).”

“ L-arginine attenuated the decrease in food intake induced by leptin.”

“The effect of leptin on the membrane fluidity was significantly potentiated by the nitric oxide (NO) donors, L-arginine and S-nitroso-N-acetylpenicillamine (SNAP), and a cyclic guanosine monophosphate (cGMP) analog, 8-bromo-cGMP.”

“DISCUSSION Ar inine in fusion transiently decreased plasma lep tin co ncentrations both in insulin-deficient and hyperinsulinemic diabetic patients, indicating a direct inhibitory effect of the amino acid but not of insulin or FFAs.”

“ l-Arginine supplementation reduced plasma levels of leptin.”

“However, arginine treatment resulted in lower serum concentrations of leptin , glucose, triglycerides, urea, glutamine, and branched-chain amino acids, higher serum concentrations of nitric-oxide metabolites, and improvement in glucose tolerance.”

“ Arginine supplementation reduced the weight of abdominal (retroperitoneal) and epididymal adipose tissues (45 and 25%, respectively) as well as serum concentrations of glucose (25%), triglycerides (23%), FFA (27%), homocysteine (26%), dimethylarginines (18-21%), and leptin (32%).”

“L-NAME pretreatment significantly reduced the effect of leptin on ACh-induced relaxation, whereas L-arginine potentiated the effect of leptin.”