supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Objective We investigated whether the … oxide (NO) precursor, l-arginine , can prevent the antidepressant-like … of the fast-acting antidepressant, ketamine , in a genetic rat model of depression, and/or induce changes in the glutamate (Glu)/N-methyl-d-aspartate receptor (NMDAR)/NO/cyclic guanosine monophosphate (cGMP) signalling pathway.”
“Results l-Arginine pre-treatment prevented the antidepressant-like effect of ketamine in the FST, as well as a ketamine-induced increase in cGMP levels in the frontal cortex and hippocampus of FSL rats.”
Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression“The antidepressant effects of ketamine were prevented by pre-treatment with l-arginine (750 mg/kg).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback