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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Arginine
drug:
Isoproterenol
Research Papers that Mention the Interaction
“Conclusions Although β-adrenergic vasodilatation seemed to be unaltered in early hypertension, l-arginine enhanced the response to isoproterenol , whereas concomitant inhibition of nitric oxide synthase by l-NMMA had no significant effect.”
β-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by l-arginine“Adrenaline and noradrenaline (and not isoproterenol ) also reduced vessel tension in the presence of L-Arginine.”
Phenylephrine Decreases Vascular Tension in Goat Arteries in Specific Circumstances“Although ISO-induced …-ODC mice administered l-Arg … ISO showed a rapid onset of systolic dysfunction and died within 48 h. Myocytes isolated from MHC-ODC mice administered l-… and altered calcium transients, suggesting an alteration in [Ca2+] homeostasis, and abbreviated action potential duration, which may contribute to arrhythmogenesis.”
“In WKY, L-arginine treatment but not captopril resulted in increased LV weight and the contractile response to ISO was blunted.”
“Interestingly, in SI/R cardiomyocytes, insulin alone at 10−7 … increased cell contraction whereas attenuated the positive inotropic response to ISO (10−9 …/l) during R as evidenced by a 18.7% reduction in peak twitch amplitude and … 23.9% reduction in calcium transient amplitude (both P < 0.05).”
“Preincubation with SNP 1 microM or L-arginine 1 mM significantly attenuated the ISO mediated-increase in cAMP content from 4.33 +/- 0.2 pmol/well (ISO 100 nM alone) to 1.48 +/- 0.36 fmol/well and 1.72 +/- 0.21 pmol/well respectively.”
“ Isoproterenol increased DT, T(+), and T(-), and these effects were attenuated by angiotensin II, L-arginine , and 8-bromo-cGMP.”
“The combination of vasoactive intestinal polypeptide antibody and NG-nitro L-arginine significantly enhanced the inhibition on 10(-6) M isoprenaline action.”
“Cytokine-pretreated ARVM that had been maintained in L-arginine-depleted medium also exhibited a depressed contractile response to isoproterenol after addition of L-arginine , but not D-arginine.”
“After beta 1-adrenergic blockade, CBF responses to isoproterenol and acetylcholine were also reduced (P < .05) by the arginine analogue.”
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